i did something similar for a show last year- one of the downsides is a file that large can be problematic to load on a slower computer. (i had a file with a backstage runlist, preshow/postshow checklist for each crew member, quick change plot, etc each on different tabs).
for a show with a larger SM team, you could use the 'track changes' feature, and leave the file on a shared computer drive. or pass a thumbdrive back and forth.