I disagree. Though it shouldn't matter to a T the formatting of your resume, our field has a great deal of focus on how paperwork looks, so your resume is just another example of that paperwork. Plus, people won't be responding to you from the actual resume, but more likely from the cover letter that the resume is attached to.----and if you don't already, you should always be putting your resume in PDF format...that way it doesn't come out wrong on other computers.
The other thing is, the cover letter is the gateway to the resume is the gateway to the interview is the gateway to the job....One little thing at each of those points that's not JUST right can prevent you from getting to the next stage. Make it SOOOO presentable that they can't NOT give you an interview. Every little thing matters...and if it turns out that it doesn't matter and you did it anyway, no biggie, but if you don't do it, and it turns out that it matters...biggie.
I think the hyperlink on the resume is not a great idea. Keep it consistent...Make it look like a hardcopy resume would look. No one will mind the extra work of having to highlight, copy and paste if they actually do want to use the digital resume itself to respond to you. And it looks cleaner.